Article
Activation mechanisms of coagulation factor IX.
Biological chemistry - 1 Jan 2000
Zögg Thomas, Brandstetter Hans
Abstract excerpt
Blood haemostasis is accomplished by a complex network of coagulatory and fibrinolytic processes. These processes have to be delicately balanced, as clinically manifested by bleeding disorders, such as haemophilia A and B. These disorders are caused by defects in coagulation factor VIII and factor IX, respectively. Following a dual strategy, we emphasise on the one hand principles conserved in most coagulation...
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