Article

The plasma Factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex

2019-05-29

Abstract excerpt

Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with 2 catalytic A subunits and 2 carrier-protective B subunits in a heterotetramer (FXIII-A 2 B 2 ). FXIII-A 2 and -B 2 subunits are synthesized separately and then assembled in plasma. Following proteolytic activation by thrombin and calcium-mediated dissociation of...

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Literature Corpus work: cb721255-7c0b-5d44-8e54-de2ccbd31c0a
DOI: 10.1101/651448

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