Article
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively.
The Journal of biological chemistry - 28 Nov 2003
Yun Thomas H, Baglia Frank A, Myles Timothy, Navaneetham Duraiswamy, López José A, Walsh Peter N, Leung Lawrence L K
Abstract excerpt
Activation of factor XI (FXI) by thrombin on stimulated platelets plays a physiological role in hemostasis, providing additional thrombin generation required in cases of severe hemostatic challenge. Using a collection of 53 thrombin mutants, we identified 16 mutants with <50% of the wild-type thrombin FXI-activating activity in the presence of dextran sulfate. These mutants mapped to anion-binding exosite (ABE)...
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