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Article

Structure and function of factor XI.

Blood - 1 Apr 2010

Emsley Jonas, McEwan Paul A, Gailani David

Abstract excerpt

Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX. Although bleeding associated with FXI deficiency is relatively mild, there has been resurgence of interest in FXI because of studies indicating it makes contributions to thrombosis and other processes associated with dysregulated coagulation. FXI is an unusual dimeric protease, with structural features that...

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Identifiers

PMID: 20110423
DOI: 10.1182/blood-2009-09-199182
PMCID: PMC4828079

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