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Article

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis.

Blood - 15 Oct 2008

Buyue Yang, Whinna Herbert C, Sheehan John P

Abstract excerpt

The role of the factor IXa heparin-binding exosite in coagulation was assessed with mutations that enhance (R170A) or reduce (R233A) stability of the protease-factor VIIIa A2 domain interaction. After tissue factor (TF) addition to reconstituted factor IX-deficient plasma, factor IX R170A supported a 2-fold increase in velocity index (slope) and peak thrombin concentration, whereas factor IX R233A had a 4- to...

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Identifiers

PMID: 18647957
DOI: 10.1182/blood-2008-01-136820
PMCID: PMC2569175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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