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Article

Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2017

Nickel Katrin F, Long Andy T, Fuchs Tobias A, Butler Lynn M, Renné Thomas

Abstract excerpt

Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form (FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from FXII's unique mechanism of activation that is induced by binding (contact) to negatively charged surfaces. Various substances have the capacity to trigger FXII contact-activation in vivo including mast cell-derived heparin,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27834692
DOI: 10.1161/ATVBAHA.116.308595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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