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Article

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

28 Jun 2022

Abstract excerpt

Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using multi-dimensional metabolic profiling in MYCN expression systems and primary patient tumors, we comprehensively characterized the metabolic landscape driven by MYCN in NB. MYCN amplification leads to...

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PMID: 35764645
DOI: 10.1038/s41467-022-31331-2

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