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Multi-omics-driven kinetic modeling reveals metabolic adaptations and vulnerabilities in BRCA1-deficient ovarian cancer

2025-10-23

Abstract excerpt

BRCA1 -deficient ovarian cancer cells undergo extensive metabolic reprogramming, yet the network-level dynamics underlying their proliferation and treatment response remain poorly resolved. Here, we construct large-scale multi-omics-driven kinetic model populations of ovarian cancer metabolism to track how tumor cells adapt to changes in nutrient use, energy production, and metabolite dynamics over time. Across B...

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Literature Corpus work
21de2b86-ba22-59f3-ac57-cdcb39c474d5
DOI
10.1101/2025.10.22.682756
Open publication

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Multi-omics-driven kinetic modeling reveals metabolic adaptations and vulnerabilities in BRCA1-deficient ovarian cancerDOI 10.1101/2025.10.22.682756
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