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The SUMO pathway in pancreatic cancer: insights and inhibition

19 Oct 2020

Abstract excerpt

An urgent medical need to develop novel treatment strategies for patients with pancreatic ductal adenocarcinoma (PDAC) exists. However, despite various efforts in the histopathological and molecular subtyping of PDAC, novel targeted or specific therapies have not been established. Posttranslational modifications (PTMs) with ubiquitin-like proteins, including small ubiquitin-like modifiers (SUMOs), mediate...

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PMID: 33071285
DOI: 10.1038/s41416-020-01119-6

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