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Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma

24 Jun 2022

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a well-known lethal and heterogeneous disease. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) is an important mutagenic driver that has seldom been investigated in PDAC. Therefore, this study investigated the significance of APOBEC3C in PDAC. First, cytosine deamination-associated mutation signatures were identified in the PDAC cohorts from TCGA...

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PMID: 35750693
DOI: 10.1038/s41389-022-00411-9

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