Article
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Nature chemical biology - 1 Jan 2020
Ross Nathan T, Lohmann Felix, Carbonneau Seth, Fazal Aleem, Weihofen Wilhelm A, Gleim Scott, Salcius Michael, Sigoillot Frederic, Henault Martin, Carl Sarah H, Rodríguez-Molina Juan B, Miller Howard R, Brittain Scott M, Murphy Jason, Zambrowski Mark, Boynton Geoffrey, Wang Yuan, Chen Aye, Molind Gregory J, Wilbertz Johannes H, Artus-Revel Caroline G, Jia Min, Akinjiyan Favour A, Turner Jonathan, Knehr Judith, Carbone Walter, Schuierer Sven, Reece-Hoyes John S, Xie Kevin, Saran Chitra, Williams Eric T, Roma Guglielmo, Spencer Matt, Jenkins Jeremy, George Elizabeth L, Thomas Jason R, Michaud Gregory, Schirle Markus, Tallarico John, Passmore Lori A, Chao Jeffrey A, Beckwith Rohan E J
Abstract excerpt
The post-genomic era has seen many advances in our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to target even monogenic tumors. Here, we combine phenotypic screening with chemical genetics to identify pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) as the target of JTE-607, a small molecule with previously...
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