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Computational analysis of genes with lethal knockout phenotype and prediction of essential genes in archaea.

mBio - 14 Feb 2024

Makarova Kira S, Zhang Changyi, Wolf Yuri I, Karamycheva Svetlana, Whitaker Rachel J, Koonin Eugene V

Abstract excerpt

The identification of microbial genes essential for survival as those with lethal knockout phenotype (LKP) is a common strategy for functional interrogation of genomes. However, interpretation of the LKP is complicated because a substantial fraction of the genes with this phenotype remains poorly functionally characterized. Furthermore, many genes can exhibit LKP not because their products perform essential...

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PMID: 38189270
DOI: 10.1128/mbio.03092-23
PMCID: PMC10865827

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