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Article

A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function.

Journal of molecular microbiology and biotechnology - 1 Jan 2003

Zalacain Magdalena, Biswas Sanjoy, Ingraham Karen A, Ambrad Jennifer, Bryant Alexander, Chalker Alison F, Iordanescu Serban, Fan Jing, Fan Frank, Lunsford R Dwayne, O'Dwyer Karen, Palmer Leslie M, So Chi, Sylvester Daniel, Volker Craig, Warren Patrick, McDevitt Damien, Brown James R, Holmes David J, Burnham Martin K R

Abstract excerpt

Attempted allelic replacement of 144 Streptococcus pneumoniae open reading frames of previously uncharacterized function led to the identification of 36 genes essential for growth under laboratory conditions. Of these, 14 genes (obg, spoIIIJ2, trmU, yacA, yacM, ydiC, ydiE, yjbN, yneS, yphC, ysxC,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15044829
DOI: 10.1159/000076741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044829-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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