Metabolic network analysis revealed distinct routes of deletion effects between essential and non-essential genes.

Abstract excerpt

Interest in essential genes has arisen recently given their importance in antimicrobial drug development. Although knockouts of essential genes are commonly known to cause lethal phenotypes, there is insufficient understanding on the intermediate changes followed by genetic perturbation and to what extent essential genes correlate to other genes. Here, we characterized the gene knockout effects by using a list of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Escherichia coli
• Share to Gene Deletion
• Share to Gene Knockout Techniques