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Article

Spatial architectures of somatic mutations in normal prostate, benign prostatic hyperplasia and coexisting prostate cancer.

Experimental & molecular medicine - 1 Feb 2024

Chae Jeesoo, Jung Seung-Hyun, Choi Eun Ji, Kim Jae Woong, Kim Na Yung, Moon Sung Won, Lee Ji Youl, Chung Yeun-Jun, Lee Sug Hyung

Abstract excerpt

This study aimed to identify somatic mutations in nontumor cells (NSMs) in normal prostate and benign prostatic hyperplasia (BPH) and to determine their relatedness to prostate cancer (PCA). From 22 PCA patients, two prostates were sampled for 3-dimensional mapping (50 normal, 46 BPH and 1 PCA samples), and 20 prostates were trio-sampled (two normal or BPH samples and one PCA sample) and analyzed by whole-genome...

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Source

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Identifiers

PMID: 38172600
DOI: 10.1038/s12276-023-01140-8
PMCID: PMC10834420

Genes

FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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