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Article

Development, maturation, and maintenance of human prostate inferred from somatic mutations.

Cell stem cell - 1 Jul 2021

Grossmann Sebastian, Hooks Yvette, Wilson Laura, Moore Luiza, O'Neill Laura, Martincorena Iñigo, Voet Thierry, Stratton Michael R, Heer Rakesh, Campbell Peter J

Abstract excerpt

Clonal dynamics and mutation burden in healthy human prostate epithelium are relevant to prostate cancer. We sequenced whole genomes from 409 microdissections of normal prostate epithelium across 8 donors, using phylogenetic reconstruction with spatial mapping in a 59-year-old man's prostate to reconstruct tissue dynamics across the lifespan. Somatic mutations accumulate steadily at ∼16 mutations/year/clone, with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33657416
DOI: 10.1016/j.stem.2021.02.005
PMCID: PMC8260206

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