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High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

2023-11-11

Abstract excerpt

Somatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we performed multi-region, single-cell DNA sequencing to characterize the SCNA landscape across multiple tumor-rich and normal tissue regions (∼125 mm 3 tissue cubes) obtained from prosta...

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Literature Corpus work
de6be146-6a58-5876-b8da-bff2fc672834
DOI
10.1101/2023.11.07.566123
Open publication

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High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissueDOI 10.1101/2023.11.07.566123
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