Article

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

2021-11-19

Abstract excerpt

<title>Abstract</title> <p>Copy number alterations (CNAs) are pervasive in advanced human cancers, but their prevalence in early-stage, localized tumors and their surrounding normal tissues is poorly characterized. To investigate this phenomenon, here we developed a method for spatially resolved single-cell CNA profiling and applied it to characterize the CNA landscape in 10,007 nuclei extracted from 70 tumor and...

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Literature Corpus work: 5d473466-18c2-59f9-852f-c09331a6acd8
DOI: 10.21203/rs.3.rs-1093341/v1

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