Article
Spatial Intratumor Genomic Heterogeneity within Localized Prostate Cancer Revealed by Single-nucleus Sequencing.
European urology - 1 Nov 2018
Su Fei, Zhang Wei, Zhang Dalei, Zhang Yaqun, Pang Cheng, Huang Yingying, Wang Miao, Cui Luwei, He Lei, Zhang Jinsong, Zou Lihui, Zhang Junhua, Li Wenqinq, Li Lin, Shao Jianyong, Ma Jie, Xiao Fei, Liu Ming
Abstract excerpt
BACKGROUND: Prostate adenocarcinoma (PCa) is a complex genetic disease, and the implementation of personalized treatment in PCa faces challenges due to significant inter- and intrapatient tumor heterogeneities. OBJECTIVE: To systematically explore the genomic complexity of tumor cells with different Gleason scores (GSs) in PCa. DESIGN, SETTING, AND PARTICIPANTS: We performed single-cell whole genome sequencing of...
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