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High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

24 Apr 2024

Abstract excerpt

Somatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we perform multi-region, single-cell DNA sequencing to characterize the SCNA landscape across tumor-rich and normal tissue in two male patients with localized prostate cancer. We identify...

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Cancer Genomics and Diagnostics
Molecular Biology Techniques and Applications
Prostate Cancer Treatment and Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38658552
DOI: 10.1038/s41467-024-47664-z

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