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Article

The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

22 Sept 2022

Abstract excerpt

Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied Whole Genome DNA Sequencing (WGS) to a group of morphologically normal tissue (n = 51), including benign prostatic hyperplasia (BPH) and non-BPH samples, from men with...

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PMID: 36131292
DOI: 10.1186/s12943-022-01644-3

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