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Article

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia

28 Apr 2020

Abstract excerpt

Fusion proteins involving Nucleoporin 98 (NUP98) are recurrently found in acute myeloid leukemia (AML) and are associated with poor prognosis. Lack of mechanistic insight into NUP98-fusion-dependent oncogenic transformation has so far precluded the development of rational targeted therapies. We reasoned that different NUP98-fusion proteins deregulate a common set of transcriptional targets that might be...

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PMID: 32344427
DOI: 10.1182/blood.2019003267

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