Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

3 Aug 2011

Abstract excerpt

Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in acute myeloid leukemia (AML) but can be missed with routine karyotyping. In this study, high-resolution genome-wide copy number analyses revealed cryptic NUP98/NSD1 translocations in 3 of 92 cytogenetically normal (CN)-AML cases. To determine their exact frequency, we screened > 1000 well-characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21813447
DOI: 10.1182/blood-2011-04-346643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression patternPMID 21813447Read ↗

NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.Semantic proximity Read ↗

NUP98 ‐ NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemiaSemantic proximity Read ↗

NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemiaSemantic proximity Read ↗

NUP98 rearrangements in adult AML patients: evaluation of clinical implications and identification of novel fusion partners.Semantic proximity Read ↗

Comprehensive mutational profiling and clinical outcome of adult acute myeloid leukemia patients with NUP98 rearrangement.Semantic proximity Read ↗

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.Semantic proximity Read ↗

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.Semantic proximity Read ↗

Identification of NUP98-NSD1 interactors and their implication in acute myeloid leukemiaSemantic proximity Read ↗

Analysis of NUP98/NSD1 translocations in adult AML and MDS patientsSemantic proximity Read ↗

NUP98 rearrangements in adult AML patients: Evaluation of clinical implications and identification of novel fusion partnersSemantic proximity Read ↗

NUP98::NSD1 and FLT3/ITD co-expression is an independent predictor of poor prognosis in pediatric AML patients.Semantic proximity Read ↗

NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.