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Article

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation.

PLoS genetics - 1 Oct 2022

Chiriches Claudia, Nicolaisen Nathalie, Wieske Maria, Elhaddad Heba, Mehmetbeyoglu Ecmel, Alvares Caroline, Becher Dörte, Hole Paul, Ottmann Oliver Gerhard, Ruthardt Martin

Abstract excerpt

The WHO classifies t(6;9)-positive acute myeloid leukemia (AML) as a subgroup of high-risk AML because of its clinical and biological peculiarities, such as young age and therapy resistance. t(6;9) encodes the DEK/NUP214 fusion oncoprotein that targets only a small subpopulation of bone marrow progenitors for leukemic transformation. This distinguishes DEK/NUP214 from other fusion oncoproteins, such as PML/RARα,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Identifiers

PMID: 36288392
DOI: 10.1371/journal.pgen.1010463
PMCID: PMC9639852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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