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Article

DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML)

12 Aug 2014

Abstract excerpt

DEK is important in regulating cellular processes including proliferation, differentiation and maintenance of stem cell phenotype. The translocation t(6;9) in Acute Myeloid Leukemia (AML), which fuses DEK with NUP214, confers a poor prognosis and a higher risk of relapse. The over-expression of DEK in AML has been reported, but different studies have shown diminished levels in pediatric and promyelocytic...

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PMID: 25128083
DOI: 10.1016/j.bcmd.2014.07.009

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