Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NUP98 rearrangements in adult AML patients: evaluation of clinical implications and identification of novel fusion partners.

Leukemia - 1 Mar 2026

Chonabayashi Kazuhisa, Iwasaki Makoto, Kanda Junya, Takamori Hiroyuki, Yoda Akinori, Kawata Takahito, Mizuta Shumpei, Sakurada Maki, Kondo Tadakazu, Hiramoto Nobuhiro, Ueda Yasunori, Gotoh Akihiko, Watanabe Mitsumasa, Kasahara Senji, Ishikawa Yuichi, Kiyoi Hitoshi, Imada Kazunori, Mitani Kinuko, Kitano Toshiyuki, Arima Nobuyoshi, Nakabo Yukiharu, Sezaki Nobuo, Kanemura Nobuhiro, Fukuda Takahiro, Ichikawa Motoshi, Miyazaki Yasushi, Fuji Shigeo, Sakata-Yanagimoto Mamiko, Yoshida Yoshinori, Takaori-Kondo Akifumi, Ogawa Seishi, Nannya Yasuhito

Abstract excerpt

NUP98 rearrangements represent a distinct, high-risk subtype of acute myeloid leukemia (AML), particularly in pediatric patients. However, their prevalence, genetic features, and clinical implications in adult AML remain poorly characterized. Using targeted-capture sequencing, we identified 41 cases with NUP98 rearrangements among 1569 AML cases, representing the majority of 44 NUP98-rearranged cases detected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Leukemia, Myeloid, Acute

Share to Nuclear Pore Complex Proteins

Share to Nucleophosmin

Share to Oncogene Proteins, Fusion

Share to Prognosis

Share to Young Adult

Source

Identifiers

PMID: 41501506
DOI: 10.1038/s41375-025-02848-4

Genes

NUP98
HOXA9
NSD1
FLT3
HOXA6
MEOX2
NPM1
TET2
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NUP98 rearrangements in adult AML patients: evaluation of clinical implications and identification of novel fusion partners.PMID 41501506Read ↗

NUP98 rearrangements in adult AML patients: Evaluation of clinical implications and identification of novel fusion partnersSemantic proximity Read ↗

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.Semantic proximity Read ↗

NUP98 Rearrangements in AML: Molecular Mechanisms and Clinical ImplicationsSemantic proximity Read ↗

Landscape of somatic mutations and clonal evolution in NUP98‐rearranged adult acute myeloid leukaemiaSemantic proximity Read ↗

NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.Semantic proximity Read ↗

Targeted gene sequencing and transcriptome sequencing reveal characteristics of NUP98 rearrangement in pediatric acute myeloid leukemia.Semantic proximity Read ↗

Comprehensive mutational profiling and clinical outcome of adult acute myeloid leukemia patients with NUP98 rearrangement.Semantic proximity Read ↗

Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape StudySemantic proximity Read ↗

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression patternSemantic proximity Read ↗

Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98 -rearranged leukemiaSemantic proximity Read ↗

NUP98::NSD1 and FLT3/ITD co-expression is an independent predictor of poor prognosis in pediatric AML patients.Semantic proximity Read ↗

NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.