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DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

9 Apr 2025

Abstract excerpt

The t(6;9)(p22.3;q34.1) translocation/DEK::NUP214 fusion protein defines a distinct subgroup of younger AML patients classified as a separate disease entity by the World Health Organization. DEK is a nuclear factor with multifunctional roles, including gene regulation, while its fusion partner, NUP214, plays a pivotal role in nuclear export by interacting with transport receptors such as XPO1. However, the...

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PMID: 40204893
DOI: 10.1038/s41375-025-02593-8

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