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NUP98 Rearrangements in AML: Molecular Mechanisms and Clinical Implications

18 Jul 2023

Abstract excerpt

NUP98 fusions constitute a small subgroup of AML patients and remain a high-risk AML subtype. There are approximately thirty types of NUP98 fusion identified in AML patients. These patients show resistance to currently available therapies and poor clinical outcomes. NUP98 fusions with different fusion partners have oncogenic transformation potential. This review describes how the NUP98 gene acquires oncogenic...

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PMID: 42164049
DOI: 10.3390/onco3030011

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