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Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98 -rearranged leukemia

23 Jul 2025

Abstract excerpt

ABSTRACT: Leukemias with NUP98 rearrangements exhibit heterogeneous phenotypes such as acute myeloid leukemia, T-cell acute lymphoblastic leukemia (T-ALL), or myelodysplastic syndrome/neoplasms associated with fusion partners, whereas the mechanism responsible for this heterogeneity is poorly understood. Through genome-wide mutational and transcriptional analyses of 177 NUP98-rearranged leukemias, we show that...

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PMID: 40700635
DOI: 10.1182/blood.2025028993

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