Article
The transcription factor Ofi1 is critical for white-opaque switching in natural MTLa/α isolates of Candida albicans.
Molecular microbiology - 1 Feb 2024
Cui Hao, Yang Dandan, Gong Shengwei, Zhang Yaling, Dong Bin, Su Chang, Yang Lianjuan, Lu Yang
Abstract excerpt
Candida albicans, an opportunistic fungal pathogen, is able to switch between two distinct cell types: white and opaque. While white-to-opaque switching is typically repressed by the a1/α2 heterodimer in MTLa/α cells, it was recently reported that switching can also occur in some natural MTLa/α strains under certain environmental conditions. However, the regulatory program governing white-opaque switching in...
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