Article
Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans.
Proceedings of the National Academy of Sciences of the United States of America - 22 Aug 2006
Huang Guanghua, Wang Huafeng, Chou Song, Nie Xinyi, Chen Jiangye, Liu Haoping
Abstract excerpt
Candida albicans, a commensal organism and a pathogen of humans, can switch stochastically between a white phase and an opaque phase without an intermediate phase. The white and opaque phases have distinct cell shapes and gene expression programs. Once switched, each phase is stable for many cell divisions. White-opaque switching is under a1-alpha2 repression and therefore only happens in a or alpha cells....
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