Article
White-opaque switching in natural MTLa/α isolates of Candida albicans: evolutionary implications for roles in host adaptation, pathogenesis, and sex.
PLoS biology - 1 Jan 2013
Xie Jing, Tao Li, Nobile Clarissa J, Tong Yaojun, Guan Guobo, Sun Yuan, Cao Chengjun, Hernday Aaron D, Johnson Alexander D, Zhang Lixin, Bai Feng-Yan, Huang Guanghua
Abstract excerpt
Phenotypic transitions play critical roles in host adaptation, virulence, and sexual reproduction in pathogenic fungi. A minority of natural isolates of Candida albicans, which are homozygous at the mating type locus (MTL, a/a or α/α), are known to be able to switch between two distinct cell types: white and opaque. It is puzzling that white-opaque switching has never been observed in the majority of natural C....
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