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Article

MTL-independent phenotypic switching in Candida tropicalis and a dual role for Wor1 in regulating switching and filamentation.

PLoS genetics - 1 Mar 2013

Porman Allison M, Hirakawa Matthew P, Jones Stephen K, Wang Na, Bennett Richard J

Abstract excerpt

Phenotypic switching allows for rapid transitions between alternative cell states and is important in pathogenic fungi for colonization and infection of different host niches. In Candida albicans, the white-opaque phenotypic switch plays a central role in regulating the program of sexual mating as well as interactions with the mammalian host. White-opaque switching is controlled by genes encoded at the MTL...

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Identifiers

PMID: 23555286
DOI: 10.1371/journal.pgen.1003369
PMCID: PMC3605238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTL-independent phenotypic switching in Candida tropicalis and a dual role for Wor1 in regulating switching and filamentation.PMID 23555286Read ↗

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White-opaque switching in Candida albicans: cell biology, regulation, and function.Semantic proximity Read ↗

N-acetylglucosamine induces white-to-opaque switching and mating in Candida tropicalis, providing new insights into adaptation and fungal sexual evolution.Semantic proximity Read ↗

The transcription factor Ofi1 is critical for white-opaque switching in natural MTLa/α isolates of Candida albicans.Semantic proximity Read ↗

Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans.Semantic proximity Read ↗

Variation in transcription regulator expression underlies differences in white-opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates.Semantic proximity Read ↗

Comparative genomics of white and opaque cell states supports an epigenetic mechanism of phenotypic switching in Candida albicans.Semantic proximity Read ↗

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Phenotypic Profiling Reveals that Candida albicans Opaque Cells Represent a Metabolically Specialized Cell State Compared to Default White Cells.Semantic proximity Read ↗

Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicansSemantic proximity Read ↗

Identification and Characterization of Wor4, a New Transcriptional Regulator of White-Opaque Switching.Semantic proximity Read ↗

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