Article
Environmental induction of white-opaque switching in Candida albicans.
PLoS pathogens - 13 Jun 2008
Ramírez-Zavala Bernardo, Reuss Oliver, Park Yang-Nim, Ohlsen Knut, Morschhäuser Joachim
Abstract excerpt
Candida albicans strains that are homozygous at the mating type locus (MTLa or MTLalpha) can spontaneously switch at a low frequency from the normal yeast cell morphology (white) to an elongated cell type (opaque), which is the mating-competent form of the fungus. The ability to switch reversibly between these two cell types also contributes to the pathogenicity of C. albicans, as white and opaque cells are...
Topics
- Adaptation, Physiological
- Animals
- Candida albicans
- Environment
- Fungal Proteins
- Intestines
- Mice
- Oxygen
- Phenotype
- Transcription Factors
- Virulence