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Article

Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans.

PLoS genetics - 1 Jan 2018

Alkafeef Selma S, Yu Clinton, Huang Lan, Liu Haoping

Abstract excerpt

The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29337983
DOI: 10.1371/journal.pgen.1007176
PMCID: PMC5786334

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Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans.PMID 29337983Read ↗

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