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Dicentric chromosomes are resolved through breakage and repair at their centromeres.

Chromosoma - 1 Apr 2024

Cook Diana, Kozmin Stanislav G, Yeh Elaine, Petes Thomas D, Bloom Kerry

Abstract excerpt

Chromosomes with two centromeres provide a unique opportunity to study chromosome breakage and DNA repair using completely endogenous cellular machinery. Using a conditional transcriptional promoter to control the second centromere, we are able to activate the dicentric chromosome and follow the appearance of DNA repair products. We find that the rate of appearance of DNA repair products resulting from...

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PMID: 38165460
DOI: 10.1007/s00412-023-00814-6
PMCID: PMC11180013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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