Article
Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae.
Genetics - 1 May 2013
Song Wei, Gawel Malgorzata, Dominska Margaret, Greenwell Patricia W, Hazkani-Covo Einat, Bloom Kerry, Petes Thomas D
Abstract excerpt
Dicentric chromosomes undergo breakage in mitosis, resulting in chromosome deletions, duplications, and translocations. In this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic recombination assay. The assay uses a diploid strain in which one homolog has a conditional centromere in addition to a wild-type centromere, and the other homolog has only the wild-type...
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