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Article

Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae.

Genetics - 1 May 2013

Song Wei, Gawel Malgorzata, Dominska Margaret, Greenwell Patricia W, Hazkani-Covo Einat, Bloom Kerry, Petes Thomas D

Abstract excerpt

Dicentric chromosomes undergo breakage in mitosis, resulting in chromosome deletions, duplications, and translocations. In this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic recombination assay. The assay uses a diploid strain in which one homolog has a conditional centromere in addition to a wild-type centromere, and the other homolog has only the wild-type...

Topics

Base Sequence
Chromosome Breakage
Chromosome Mapping
Chromosomes, Fungal
Loss of Heterozygosity
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

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Identifiers

PMID: 23410835
DOI: 10.1534/genetics.113.150144
PMCID: PMC3632482

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