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Article

Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae.

The Journal of cell biology - 17 Mar 2003

Mythreye Karthikeyan, Bloom Kerry S

Abstract excerpt

Dicentric chromosomes undergo a breakage-fusion-bridge cycle as a consequence of having two centromeres on the same chromatid attach to opposite spindle poles in mitosis. Suppression of dicentric chromosome breakage reflects loss of kinetochore function at the kinetochore-microtubule or the kinetochore-DNA interface. Using a conditionally functional dicentric chromosome in vivo, we demonstrate that kinetochore...

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Identifiers

PMID: 12642611
DOI: 10.1083/jcb.200211116
PMCID: PMC2173759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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