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Article

Epigenetic inactivation and subsequent heterochromatinization of a centromere stabilize dicentric chromosomes.

Current biology : CB - 24 Apr 2012

Sato Hiroshi, Masuda Fumie, Takayama Yuko, Takahashi Kohta, Saitoh Shigeaki

Abstract excerpt

BACKGROUND: The kinetochore is a multiprotein complex that forms on a chromosomal locus designated as the centromere, which links the chromosome to the spindle during mitosis and meiosis. Most eukaryotes, with the exception of holocentric species, have a single distinct centromere per chromosome, and the presence of multiple centromeres on a single chromosome is predicted to cause breakage and/or loss of that...

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Identifiers

PMID: 22464190
DOI: 10.1016/j.cub.2012.02.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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