Article

Multi-omics insights in major depressive disorder: Dysfunction of Neurons

2025-05-05

Abstract excerpt

Major Depressive Disorder (MDD) is a complex psychiatric condition characterized by neuronal and functional disruptions in the dorsolateral prefrontal cortex (dlPFC). We integrated MDD-associated multi-omics data, including two single-cell RNA sequencing (scRNA-seq) datasets, GWAS summary data, and depression-related proteomic data from UK Biobank. We identified 273 MDD-associated eQTL, while the single-cell disea...

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Literature Corpus work: e1002231-312f-5dea-8d60-c973e16d9893
DOI: 10.1101/2025.05.03.25326369

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