Article

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

2022-09-26

Abstract excerpt

Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-exi...

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Literature Corpus work: de9641c6-77a8-5c0b-91f1-596c60b1ed4d
DOI: 10.1101/2022.09.23.509254

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