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Article

Highly cooperative chimeric super-SOX induces naive pluripotency across species

22 Dec 2023

Abstract excerpt

Our understanding of pluripotency remains limited: iPSC generation has only been established for a few model species, pluripotent stem cell lines exhibit inconsistent developmental potential, and germline transmission has only been demonstrated for mice and rats. By swapping structural elements between Sox2 and Sox17, we built a chimeric super-SOX factor, Sox2-17, that enhanced iPSC generation in five tested...

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PMID: 38141611
DOI: 10.1016/j.stem.2023.11.010

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