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The emergence of Sox and POU transcription factors predates the origins of animal stem cells

14 Nov 2024

Abstract excerpt

Stem cells are a hallmark of animal multicellularity. Sox and POU transcription factors are associated with stemness and were believed to be animal innovations, reported absent in their unicellular relatives. Here we describe unicellular Sox and POU factors. Choanoflagellate and filasterean Sox proteins have DNA-binding specificity similar to mammalian Sox2. Choanoflagellate—but not filasterean—Sox can replace...

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PMID: 39543096
DOI: 10.1038/s41467-024-54152-x

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