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Enhancing Sox/Oct cooperativity induces higher-grade developmental reset

2022-09-25

Abstract excerpt

<h4>ABSTRACT</h4> The discovery of induced pluripotent stem cell (iPSC) technology by Shinya Yamanaka has truly enabled the stem cell field. After 16 years of intense research, the delivery methods and culture media have improved but the original factors—Oct4, Sox2, Klf4, and Myc (OSKM)—remain central for driving reprogramming. Here we define structural elements in chimeric Sox2/Sox17 transcription factors that r...

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Identifiers and source

Literature Corpus work
b2d49143-eed4-5380-98a2-3b4621dfe648
DOI
10.1101/2022.09.23.509242
Open publication

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Enhancing Sox/Oct cooperativity induces higher-grade developmental resetDOI 10.1101/2022.09.23.509242
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