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Article

KLF4 N-terminal variance modulates induced reprogramming to pluripotency.

Stem cell reports - 14 Apr 2015

Kim Shin-Il, Oceguera-Yanez Fabian, Hirohata Ryoko, Linker Sara, Okita Keisuke, Yamada Yasuhiro, Yamamoto Takuya, Yamanaka Shinya, Woltjen Knut

Abstract excerpt

As the quintessential reprogramming model, OCT3/4, SOX2, KLF4, and c-MYC re-wire somatic cells to achieve induced pluripotency. Yet, subtle differences in methodology confound comparative studies of reprogramming mechanisms. Employing transposons, we systematically assessed cellular and molecular hallmarks of mouse somatic cell reprogramming by various polycistronic cassettes. Reprogramming responses varied in...

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Source

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Identifiers

PMID: 25772473
DOI: 10.1016/j.stemcr.2015.02.004
PMCID: PMC4400650

Genes

KLF4
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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