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Article

Induced pluripotent reprogramming from promiscuous human stemness related factors.

Clinical and translational science - 1 Apr 2009

Nelson Timothy J, Martinez-Fernandez Almudena, Yamada Satsuki, Mael Amber A, Terzic Andre, Ikeda Yasuhiro

Abstract excerpt

Ectopic expression of pluripotency gene sets provokes nuclear reprogramming in permissive somatic tissue environments generating induced pluripotent stem (iPS) cells. The evolutionary conserved function of stemness orthologs was here tested through interspecies transduction. A spectrum of HIV-based lentiviral vectors was designed, and point mutations in the HIV-1 capsid region identified for efficient infectivity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20161095
DOI: 10.1111/j.1752-8062.2009.00091.x
PMCID: PMC2745150

Genes

KLF4
MYC
SOX2

Provenance

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