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Article

Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells

13 Oct 2010

Abstract excerpt

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by transduction of reprogramming factors, including Oct4, Sox2, Klf4, and c-Myc. A coordinated network of these factors was suggested to confer a pluripotency of iPSCs. Together with Oct4, Sox2 plays a major role as a master regulator in ESCs. However, the underlying mechanisms by which Sox2 contributes to self-renewal or reprogramming...

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PMID: 20945330
DOI: 10.1002/stem.540

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