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Article

Neural Network Connectivity Following Opioid Dependence is Altered by a Common Genetic Variant in the µ-Opioid Receptor, OPRM1 A118G.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Feb 2024

Xie Yihan, Brynildsen Julia K, Windisch Kyle, Blendy Julie A

Abstract excerpt

Opioid use disorder is a chronic, relapsing disease associated with persistent changes in brain plasticity. A common single nucleotide polymorphism (SNP) in the µ-opioid receptor gene, OPRM1 A118G, is associated with altered vulnerability to opioid addiction. Reconfiguration of neuronal connectivity may explain dependence risk in individuals with this SNP. Mice with the equivalent Oprm1 variant, A112G,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38124015
DOI: 10.1523/JNEUROSCI.1492-23.2023
PMCID: PMC10866092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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