Article
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
Scientific reports - 7 Oct 2022
Gaddis Nathan, Mathur Ravi, Marks Jesse, Zhou Linran, Quach Bryan, Waldrop Alex, Levran Orna, Agrawal Arpana, Randesi Matthew, Adelson Miriam, Jeffries Paul W, Martin Nicholas G, Degenhardt Louisa, Montgomery Grant W, Wetherill Leah, Lai Dongbing, Bucholz Kathleen, Foroud Tatiana, Porjesz Bernice, Runarsdottir Valgerdur, Tyrfingsson Thorarinn, Einarsson Gudmundur, Gudbjartsson Daniel F, Webb Bradley Todd, Crist Richard C, Kranzler Henry R, Sherva Richard, Zhou Hang, Hulse Gary, Wildenauer Dieter, Kelty Erin, Attia John, Holliday Elizabeth G, McEvoy Mark, Scott Rodney J, Schwab Sibylle G, Maher Brion S, Gruza Richard, Kreek Mary Jeanne, Nelson Elliot C, Thorgeirsson Thorgeir, Stefansson Kari, Berrettini Wade H, Gelernter Joel, Edenberg Howard J, Bierut Laura, Hancock Dana B, Johnson Eric Otto
Abstract excerpt
Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling to conduct a GWAS of the new Genetics of Opioid Addiction Consortium (GENOA) data together with published studies (Psychiatric Genomics Consortium, Million Veteran Program,...
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