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Article

Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Mechling Anna E, Arefin Tanzil, Lee Hsu-Lei, Bienert Thomas, Reisert Marco, Ben Hamida Sami, Darcq Emmanuel, Ehrlich Aliza, Gaveriaux-Ruff Claire, Parent Maxime J, Rosa-Neto Pedro, Hennig Jürgen, von Elverfeldt Dominik, Kieffer Brigitte Lina, Harsan Laura-Adela

Abstract excerpt

Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity; however, the causal impact of a single gene's activity on whole-brain networks remains unknown. We tested whether the sole targeted deletion of the mu opioid receptor gene (Oprm1) alters the brain connectome in living mice. Hypothesis-free analysis of combined resting-state fMRI diffusion tractography showed pronounced...

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Identifiers

PMID: 27671662
DOI: 10.1073/pnas.1601640113
PMCID: PMC5068324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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